Nebivolol reduces heart rate and cardiac workload while also producing vasodilatory effects. Hydrochlorothiazide increases the excretion of sodium and water through the kidneys, reducing circulating fluid volume. Together, they help lower and maintain blood pressure.
Indications :
- Essential hypertension (high blood pressure)
- Hypertension inadequately controlled with a single antihypertensive medicine
- Patients who require the combined antihypertensive effects of nebivolol 5 mg + hydrochlorothiazide 12.5 mg
- Maintenance of blood-pressure control in patients already controlled on the two medicines given together.
Common Side Effects :
- Dizziness
- Headache
- Fatigue or tiredness
- Increased urination
- Slow heart rate (bradycardia)
- Nausea or stomach discomfort
- Mild weakness
Hydrochlorothiazide may also cause electrolyte disturbances, while nebivolol can lower heart rate and blood pressure.
Precautions :
- Monitor blood pressure and pulse regularly.
- Periodic monitoring of kidney function and electrolytes, particularly sodium and potassium, may be required.
- Use cautiously in patients with diabetes, as beta-blockers can mask some symptoms of low blood sugar and hydrochlorothiazide may affect glucose levels.
- Use cautiously in patients with asthma or bronchospastic disease.
- Patients with gout or high uric acid should inform their doctor because hydrochlorothiazide can increase uric acid.
- Patients with significant kidney or liver impairment require particular medical supervision; the fixed-dose combination should not be used in severe renal impairment and is contraindicated in certain hepatic impairment situations.
- Do not stop nebivolol suddenly, as abrupt withdrawal can cause worsening of cardiovascular symptoms.
Important: This is prescription medicine.always take it under docto's advice & The dose should not be changed or discontinued without the prescribing doctor's advice.
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