Montelukast (10 mg) + Fexofenadine (120 mg) is commonly prescribed for the management of allergic disorders involving the respiratory tract and skin.
Montelukast blocks leukotriene receptors, reducing airway inflammation, bronchoconstriction, and mucus production.
Fexofenadine blocks peripheral H1-histamine receptors, relieving symptoms like sneezing, itching, and runny nose without significant sedation.
This combination provides dual-action relief in allergic conditions by targeting both histamine-mediated and leukotriene-mediated pathways.
📌 Indications :
Allergic rhinitis (seasonal & perennial)
Sneezing and nasal congestion
Runny nose (rhinorrhea)
Itchy/watery eyes
Chronic urticaria (hives)
Allergic cough
Adjunct therapy in mild bronchial asthma (allergy-induced)
⚠️ Precautions :
Monitor blood glucose regularly to avoid hypoglycemia
Use cautiously in renal impairment (check serum creatinine)
Avoid in severe hepatic dysfunction
Risk of lactic acidosis (rare but serious, mainly due to metformin)
Avoid excessive alcohol consumption
Temporarily discontinue before contrast imaging procedures
Elderly patients require dose monitoring
Not recommended in Type 1 Diabetes or diabetic ketoacidosis.
🚨 Side Effects :
Common:
Hypoglycemia (sweating, dizziness, tremors)
Nausea, vomiting
Diarrhea
Abdominal discomfort
Metallic taste
Less Common but Serious:
Lactic acidosis
Vitamin B12 deficiency (long-term use)
Weight gain (due to glimepiride)
Allergic skin reactions
🌡️ Storage Temperature :
Store below 25°C
Protect from moisture and direct sunlight
Keep in original packaging
Keep out of reach of children
